One of the earliest white settlements in the Old Creek Indian Nation. James Elizabeth Glenn, who named the town, and his brother Thompson Glenn, arrived here in 1835 only to have to evacuate during the Indian uprisings of 1836, at which time all buildings were destroyed and the remaining settlers killed. Thompson Glenn is credited with effecting the removal, to Columbus Georgia, of the entrapped white citizens of nearby Roanoke, Georgia, during the same uprising. Glennville was resettled upon the removal of the Indians. It rapidly attracted settlers and their social and cultural standards caused Glennville to be known as "The Athens of the South."
At its Apex this town had collegiate institutes. Finishing schools an military academy, classic churches and stately home in 1854 John Bowles Glenn, let here to establish a school at Auburn and became its first resident of the board of trustees. This school in successive changes became Auburn University. Glennville was the home of the only known Lynch Bob that brought a newspaper advertisement acknowledged The deed and published their names the victim a convicted murders. was a member of the Prominent Barbour county white family the incident brought national attention to town. The failure to accept a railroad, seen as "An intrusion on their way of living". Proved to be the herald of the town's demise.