Henry Pfluger (1803-67), who migrated from Germany to Texas in 1849-50, moved his large family here in 1853. Other settlers joined them, and in 1872 a school was begun on Henry Lisso's farm. Immanuel Lutheran Church was founded in 1874. Primarily a farming settlement, Pflugerville had no commercial businesses until 1890, when Louis Bohls built a general store. A post office was opened there in 1893 with Bohls as postmaster. In 1891 two community organizations were formed: the German-American Mutual Assurance Association, to insure townspeople against natural disasters; and "Pflugerville Schuetzen and kegel verain," a shooting and bowling club.
The village began to grow when the Missouri, Kansas & Texas Railroad arrived in 1904, George Pfluger (1834-1910) and his son Albert (1878-1969) platted the townsite, and George donated land for a train depot and a school. Early businesses included drugstores, groceries, a hotel, grist mill, cotton gin, ice factory and Archie Ward started a telephone system. Farmers State Bank, chartered in 1906, became First State Bank in 1933. A newspaper "The Pflugerville Press," was published from 1907 until 1942.
In 1958-62, the Pflugerville High School football team gained national fame by winning 55 consecutive games.